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This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. • Directly in front of a number (numeric literal) and when it is not a subtraction operator it means a negative number! This vaccine increases cytotoxic-lymphocyte responses specific for varicella–zoster virus in seropositive elderly persons.

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